QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective an...

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Bibliographische Detailangaben
Hauptverfasser: JAMES H. COOK, II, DALTON KING, IVAR M. MCDONALD, CHRISTIANA I. IWUAGWU, F. CHRISTOPHER ZUSI, RICHARD E. OLSON, NENGHUI WANG, JOHN E. MACOR
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders. La descripción proporciona compuestos de fórmula I, incluyendo sus sales, así como composiciones y procedimientos de uso de los compuestos. Los compuestos son ligandos para el receptor nicotínico a7 y pueden ser útiles para el tratamiento de diversos trastornos del sistema nervioso central, en especial trastornos afectivos y neurodegenerativos. (ver fórmula (I)).