COMPOUNDS AND METHOD FOR REDUCING URIC ACID

Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. In Formula (I) m is 0, 1, 2, 3 or 4; n is 0 or 1; m + n is not more than 4; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, methyl or ethyl and R12 is hydrogen or methyl, or R6 is hydroxy and R12 is hydrogen, or R6 is O and R12 is absent, or R6 and R12 together are -CH2CH2-. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula (I) by a ring carbon; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula (I) are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, and cognitive impairment. El ácido úrico en sujetos mamíferos se reduce y la excreción de ácido úrico se incrementa al administrar un compuesto de la Fórmula (I) o una sal farmacéuticamente aceptable del mismo. En la fórmula (I), m es 0, 1, 2, 3 o 4; n es 0 o 1; m+ n no es mayor que 4; t es 0 o 1; q es 0 o 1; y r es 0, 1 o 2. R6 es hidrógeno, metilo o etilo y R12 es hidrógeno o metilo, o R6 es hidroxi y R12 es hidrógeno, o R6 es O y R12 está ausente, o R6 y R12 juntos son -CH2CH2-. R7 es hidrógeno o alquilo que tiene de 1 a 3 átomos de carbono. Uno de R8 y R9 es alquilo que tiene de 1 a 3 átomos de carbono y el otro es hidrógeno o alquilo que tiene de 1 a 3 átomos de carbono. R10 es hidrógeno, halo, al