BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases. Se describen compuestos de fórmula A: (ver fórmula I) y sales farmacéuticamente aceptables de los mismos, q...

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Hauptverfasser: DI GRANDI, MARTIN JOSEPH, HOPPER, DARRIN WILLIAM, WANG, XIAOLUN, TORRES, NANCY, DUTIA, MINU DHANJISH, ZHANG, CHUNCHUN, DUNNICK, ALEJANDRO LEE, LEVIN, JEREMY IAN
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula A and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases. Se describen compuestos de fórmula A: (ver fórmula I) y sales farmacéuticamente aceptables de los mismos, que inhiben selectivamente la actividad Raf quinasa y son útiles para tratar trastornos mediados por Rafquinasas.