IL-17RA-IL-17RB ANTAGONISTS AND USES THEREOF
The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as v...
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| Format: | Patent |
| Sprache: | eng ; spa |
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| Zusammenfassung: | The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.
La presente invención se refiere al ligando de lnterleucina-17 y a los miembros de la familia del receptor y el descubrimiento de que el receptor IL-17 A y el receptor IL-17 C forman un complejo receptor heteromérico que es biológicamente activo. Se describen los antagonistas del complejo receptor heteromérico IL-I7RA-IL-I7RB, así como varios métodos de uso. |
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