IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;. Se describen compuestos de la fórmula 1 que inhiben las cinasas de proteína, composiciones que contienen compuestos y métodos para tratar enfermedades utilizando los compuestos. La fórmula I y las sales terapéuticamente aceptables, profármacos y sales de los profármacos de los mismos, en donde X es CH o N; A1 es R1, OR1. NHR1, N(R1)2 NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, o C(NH2)NOC(O)R1.