WET GRANULATION USING A WATER SEQUESTERING AGENT

WET GRANULATION USING A WATER SEQUESTERING AGENT

Disclosed are tablets comprising hydrolytically stable formulations of (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino) pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]ox azin-4(3H)-yl)methyl phosphate disodium salt (Compound 1) prepared by a wet granulation process. Se describen tabletas q...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: THOMAS SUN, RAY LO
Format: Patent
Sprache:eng ; spa
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed are tablets comprising hydrolytically stable formulations of (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino) pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]ox azin-4(3H)-yl)methyl phosphate disodium salt (Compound 1) prepared by a wet granulation process. Se describen tabletas que comprenden formulaciones estables hidrolíticamente de sal disódica de (6-(5-flúor-2-(3,4,5-trimetoxi fenilamino)pirimidin-4-ilamino)-2,2-dimetil- 3-oxo-2H-pirido[3,2-b ] [1,4]oxazin-4(3H)-il)metil fosfato (compuesto 1) preparado por un proceso de granulación en húmedo.