TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS

Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. Th...

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Hauptverfasser: REGINALD O. CANN, XINHUA QIAN, LAWRENCE J. KENNEDY, JEFFREY A. ROBL, RAJENDRA P. DESHPANDE, JAMES J. LI, JUN LI, CHENKUO WEI, LAXMA R. KOLLA, JIE JACK LI, MICHAEL GALELLA, HAIXIA WANG
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R3, R3a, and R3b are defined herein. La presente invenci?n se refiere a nuevos compuestos que son inhibidores de 11-beta-hidroxiesteroide deshidrogenasa tipo 1. Los inhibidores de 11-beta-hidroxiesteroide deshidrogenasa tipo I son ?tiles en tratamiento, prevenci?n o disminuci?n de la progresi?n de enfermedades que requieren tratamiento con inhibidor de 11-beta-hidroxiesteroide deshidrogenasa tipo I. Estos nuevos compuestos de f?rmula I: o sus estereois?meros o sales farmac?uticamente aceptables, en donde G, Q, X, Y, R3, R3a y R3b se definen en la presente.