ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of co...

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Hauptverfasser: CASEY CAMERON MC COMAS, JOEL ADAM GOLDBERG, PUWEN ZHANG, RICHARD PAGE WOODWORTH, JR, JOSEPH P. SABATUCCI, PAIGE ERIN MAHANEY, EUGENE ANTHONY TEREFENKO, ANDREW FENSOME, CHARLES WILLIAM MANN, DOUGLAS JOHN JENKINS, EUGENE JOHN TRYBULSKI, MATTHEW L. CRAWLEY, MICHAEL ANTHONY MARELLA, STEPHEN TODD COHN, AN THIEN VU, CALLAIN YOUNGHEE KIM, DAVID JOHN O'NEILL
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders. La presente invención se dirige a derivados de ant sulfamida de la fórmula 1: (ver fórmula (I)) una sal farmacéuticamente aceptable, estereoisómero o tautómero de estos, que son inhibidores de recaptación de monoamina, composiciones que contienen estos derivados, y métodos para su uso para la prevención y tratamiento de afecciones, que incluyen, ínter alia, síntomas vasomotrices, disfunción sexual, trastornos gastrointestinales y trastorno genitourinario, trastornos depresivos, trastornos de comportamiento endogéno, trastornos cognitivos, neuropatía diabética, dolor, y otros enfermedades y trastornos.