NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID

The invention relates to a diastereoselective method for obtaining a primary amine on a steroid, comprising the reduction of an oxime by lithium in ammonia at a low temperature in an ether/alcohol mixture. La invención se refiere a un método diaestereoselectivo para obtener una amina primaria en un...

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Bibliographische Detailangaben
Hauptverfasser: ANDRE SIMONNET, DANIEL BERNARD, GILLES ODDON, JOELLE BOUSQUET-FRANCES, GERARD CAZENAVE
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The invention relates to a diastereoselective method for obtaining a primary amine on a steroid, comprising the reduction of an oxime by lithium in ammonia at a low temperature in an ether/alcohol mixture. La invención se refiere a un método diaestereoselectivo para obtener una amina primaria en un esteroide, que consiste en la reducción de una oxima mediante litio en el amoniaco a una temperatura baja en una mezcla de alcohol y éter.