NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7

The invention relates to products of the formula (I) in which : X-Y is NH-C(S), N=C-NR7R8, N=C-SR, N=C-R or N=C-OR; R and R1 are H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, aryl or heteroaryl,; R2 is H, Hal or alkyl; R3 is H, Hal, OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is essentially H, Hal, OH, NR7R8, cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy; with R7 et R8 being such that one is H or optionally substituted alk, while the other is H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl; or with R7 and R8 forming together with N an optionally substituted cyclic radical optionally containing O, S or N. The invention also relates to isomers and salts thereof used as drugs and essentially as protein kinase inhibitors, in particular CDC7. La invención se refiere a productos de la fórmula (I) en la que: X-Y representa NH-C(S), N=C-NR7R8, N=C-SR, NC=R, o N=C-OR; R y R1 representan H, cicloalquilo, alquilo, heterocicloalquilo, arilo o heteroarilo, sustituidos opcionalmente; R2 representa H, Hal o alquilo; R3 representa H, Hal, OH, alquilo o alcoxi; R4 representa H, Hal, CN o alquilo; R5 representa esencialmente H, Hal, OH, NR7R8, cicloalquilo, alquilo, alcoxi, heterocicloalquilo, arilo o heteroarilo, sustituidos opcionalmente; R6 representa H, Hal, OH, NH2, NHalq, N(alq)2, alquilo o alcoxi; con R7 y R8 tales que uno representa H o alq sustituido opcionalmente; y el otro representa H, cicloalquilo, alquilo, heterocicloalquilo, heteroarilo o arilo, sustituidos opcionalmente; o R7 y R8 forman junto con N un radical cíclico, que contiene opcionalmente O, S o N sustituido opcionalmente; sus isómeros y sus sales, como medicamentos y esencialmente como inhibidores de quinasas, en particular de CDC7.