DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10

DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10

The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase type 10 (PDE 10) inhibitors, processes for their preparation, pharmaceutical compositions containing t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SWAMY KESHAVAPURA HOSAMANE SREEDHARA, HAVALE SHRIKANT, BALASUBRAMANIAN GOPALAN, DHAMJEWAR RAVI
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase type 10 (PDE 10) inhibitors, processes for their preparation, pharmaceutical compositions containing them and their use in treating allergic and inflammatory diseases as well as for inhibiting the production of Tumor Necrosis Factor(TNF-α). La presente invención se refiere a compuestos heterocíclicos novedosos que son útiles como inhibidores de fosfodiesterasa (PDEs), en particular inhibidores de fosfodiesterasa tipo 4 (PDE IV) e inhibidores de fosfodiesterasa tipo 10 (PDE 10), a procesos para su preparación, a composiciones farmacéuticas que los contienen y a su uso para tratar enfermedades alérgicas e inflamatorias así como para inhibir la producción de factor de necrosis de tumor (TNF-a). (ver fórmula (I)).