METHODS FOR REDUCING PROTEIN AGGREGATION

METHODS FOR REDUCING PROTEIN AGGREGATION

Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations. Se...

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Bibliographische Detailangaben
Hauptverfasser: THOMAS JOSEPH CROWLEY, ERIN CHRISTINE SOLEY, LI LI, NICHOLAS GARY LUKSHA, EDIE ANNA NEIDHARDT, NICHOLAS WILLIAM WARNE, ANGELA KANTOR
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations. Se proporcionan métodos para reducir la agregación de una proteína o proteínas en una formulación, y formulaciones de proteínas que tienen propiedades de agregación reducidas. Los métodos y formulaciones aquí descritos mantienen la actividad biológica de una proteína e incrementan el tiempo de conservación de formulaciones de proteínas.