METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS

The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identificati...

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Bibliographische Detailangaben
Hauptverfasser:	BORIS LABKVOSKY, ROHINTON P. EDALJI, EDWARD T. OLEJNICZAK, ANA PERADA-LOPEZ, THOMAS F. HOLZMAN, JOHN E. HARLAN, LIPING YU
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays. La presente invención se refiere a la clonación, expresión y aislamiento de formas recombinantes de proteína beta-amiloide conteniendo una metionina N-terminal (o uno o más aminoácidos) así como a métodos para utilizar esta proteína recombinante en la producción de anticuerpos terapéuticos, en la identificación de moléculas pequeñas terapéuticas, y en la realización de ensayos de diagnóstico.