NOVEL HIGH AFFINITY THIOPHENE-BASED AND FURAN-BASED KINASE LIGANDS

Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms . Said inhibitors are furane or thiophene derivatives. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms. Se describen inhibidores de cinasa 2 dependiente de ciclina, composiciones incluyendo los inhibidores, y metodos de uso de los inhibidores y composiciones inhibidoras; los inhibidores y composiciones que los incluyen son utiles para el tratamiento de una enfermedad o sintomas de enfermedad; dichos inhibidores son derivados de furano o tiofeno; la invencion tambien provee metodos para la elaboracion de compuestos inhibidores CDK-2, metodos para inhibir CDK-2, y metodos para el tratamiento de una enfermedad o sintomas de enfermedad.