IMMUNOLIPOSOME COMPOSITION FOR TARGETING TO A HER2 CELL RECEPTOR

An immunoliposome composition comprised of liposomes bearing a ligand for targeting to cells expressing a growth factor receptor, such as HER2, is described. Binding of the immunoliposome to HER2-expressing cells results in internalization of the immunoliposome for cytoplasmic delivery of an entrapp...

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Bibliographische Detailangaben
Hauptverfasser: NAJAFI, AZAR, KELLEY, LAURA, GUO, LUKE, ABRA, ROBERT, HUANG, ANTHONY, HJORTSVANG, KRISTEN, WONG, FRANCIS M.P
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:An immunoliposome composition comprised of liposomes bearing a ligand for targeting to cells expressing a growth factor receptor, such as HER2, is described. Binding of the immunoliposome to HER2-expressing cells results in internalization of the immunoliposome for cytoplasmic delivery of an entrapped drug. Se describe una composicion de inmunoliposoma comprendida de liposomas que contienen un ligando para el direccionamiento a las celulas que expresan un receptor del factor de crecimiento, tal como HER2; la union del inmunoliposoma a las celulas que expresan HER2 resulta en la internalizacion de inmunoliposoma para la administracion citoplasmica de un farmaco atrapado.