FUNCTIONAL ASSAYS FOR CHOLESTEROL ABSORPTION INHIBITORS

The present invention relates to functional assays performed in C.elegans worms that are useful for the identification of NPC1 L1 inhibitors. Compositions useful for the performance of such assays are also provided. La presente invencion se relaciona con ensayos funcionales realizados en gusanos de...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, MARSHA M, LEVITAN, DIANE J
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to functional assays performed in C.elegans worms that are useful for the identification of NPC1 L1 inhibitors. Compositions useful for the performance of such assays are also provided. La presente invencion se relaciona con ensayos funcionales realizados en gusanos de C. elegans que son utiles para la identificacion de inhibidores de NPC1L1; tambien se proporcionan composiciones utiles para la realizacion de tales ensayos.