INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53

INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53

The present invention provides compounds of formula (I), their use as an inhibitorof a p53-MDM2 interaction as well as pharmaceutical compositions comprisingsaid compounds of formula (I) wherein n, m, p, s, t, R1, R2,R3, R4, R5, R6, R7, X, Y, Qand Z have defined meanings. La presente invencion prove...

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Hauptverfasser: LACRAMPE, JEAN FERNAND ARMAND, ARTS, JANINE, WERMUTH, CAMILLE GEORGES, GIETHLEN, BRUNO, CONTRERAS, JEAN-MARIE, CSOKA, IMRE CHRISTIAN FRANCIS, LIGNY, YANNICK AIME EDDY, VAN HIJFTE, LUC, MEYER, CHRISTOPHE, SCHOENTJES, BRUNO, JOUBERT, MURIEL
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides compounds of formula (I), their use as an inhibitorof a p53-MDM2 interaction as well as pharmaceutical compositions comprisingsaid compounds of formula (I) wherein n, m, p, s, t, R1, R2,R3, R4, R5, R6, R7, X, Y, Qand Z have defined meanings. La presente invencion provee compuestos de formula (I), su uso como inhibidor de una interaccion p53-MDM2, como asi tambien composiciones farmaceuticas que comprenden dichos compuestos de formula (I) (Ver Formula I) en los cuales n, m, p, r, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q y Z tienen significados definidos.