ASSOCIATION OF N-{[(7S)-3,4- DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL]METHYL}-3-(7,8-DIMETHOXY- 1,2,4,5-TETRAHYDRO-3H-3-BENZAZEPIN-3-YL)-N-METHYL-3-OXO-1-PROPANAMINE AND PERINDOPRIL

ASSOCIATION OF N-{[(7S)-3,4- DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL]METHYL}-3-(7,8-DIMETHOXY- 1,2,4,5-TETRAHYDRO-3H-3-BENZAZEPIN-3-YL)-N-METHYL-3-OXO-1-PROPANAMINE AND PERINDOPRIL

Combination (I) comprises a selective and specific sinusal I f(mixed sodium ion-potassium ion inward current) current inhibitor (A) and an angiotensin converting enzyme inhibitor (B). An independent claim is included for pharmaceutical compositions comprising: ivabradine, in the form of hydrochlorid...

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Bibliographische Detailangaben
Hauptverfasser: FELDMANN, Luc, VILAINE, Jean-Paul, THUILLEZ, Christian, FRATACCI, Marie-Dominique, ROUSSEL, Jérôme, MULDER, Paulus, LEREBOURS-PIGEONNIERE, Guy
Format: Patent
Sprache:eng ; fre ; ger
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MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Combination (I) comprises a selective and specific sinusal I f(mixed sodium ion-potassium ion inward current) current inhibitor (A) and an angiotensin converting enzyme inhibitor (B). An independent claim is included for pharmaceutical compositions comprising: ivabradine, in the form of hydrochloride or its hydrate or crystalline forms, and perindopril, in the form of salt of tert-butylamine or arginine or their hydrates or crystalline forms, alone or in combination with one or more excipient. ACTIVITY : Cardiant; Cardiovascular-Gen.; Vasotropic; Antianginal; Antiarrhythmic. MECHANISM OF ACTION : Sinusal I fcurrent inhibitor; Angiotensin converting enzyme inhibitor.