PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL
Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidina...
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| creator | BADER, Thomas HORNS, Stefan PORSTMANN, Frank, Ralf |
| description | Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidinafto[2,l-d:l',2'-f][l,3,2]dioksafosfepin 4-oksidom ili nekim njegovim derivatom, a posebno sa (1 lbR)-4-hidroksidinafto[2,l-d:r,2'- f][l,3,2]dioksafosfepin 4-oksidom, kao agensom za rezoluciju.
The present invention relates to a process for isolating (αS, R)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent. |
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The present invention relates to a process for isolating (αS, R)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.</description><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131220&DB=EPODOC&CC=ME&NR=01445B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131220&DB=EPODOC&CC=ME&NR=01445B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BADER, Thomas</creatorcontrib><creatorcontrib>HORNS, Stefan</creatorcontrib><creatorcontrib>PORSTMANN, Frank, Ralf</creatorcontrib><title>PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL</title><description>Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidinafto[2,l-d:l',2'-f][l,3,2]dioksafosfepin 4-oksidom ili nekim njegovim derivatom, a posebno sa (1 lbR)-4-hidroksidinafto[2,l-d:r,2'- f][l,3,2]dioksafosfepin 4-oksidom, kao agensom za rezoluciju.
The present invention relates to a process for isolating (αS, R)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjE0LgjAYx710iOojBDsq9EC-1H3aYxvMbc0FSYRIrFOUYB-jD52K907_H_-3uffVRmVYliRXhmiDmhouj8SnQjNKyg1J0VJiAthDalShYAzgGoF_4AVaVglacKmCEW8QwWCqSzUVQ5BUM8uoQFkJGN5As5FjOJ37peAS-wntaenNHs2zc6tJF946R5sxcO27dl3b3N3LfeoCt2GS7NL4X_4D_iY9YA</recordid><startdate>20131220</startdate><enddate>20131220</enddate><creator>BADER, Thomas</creator><creator>HORNS, Stefan</creator><creator>PORSTMANN, Frank, Ralf</creator><scope>EVB</scope></search><sort><creationdate>20131220</creationdate><title>PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL</title><author>BADER, Thomas ; HORNS, Stefan ; PORSTMANN, Frank, Ralf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ME01445B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BADER, Thomas</creatorcontrib><creatorcontrib>HORNS, Stefan</creatorcontrib><creatorcontrib>PORSTMANN, Frank, Ralf</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BADER, Thomas</au><au>HORNS, Stefan</au><au>PORSTMANN, Frank, Ralf</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL</title><date>2013-12-20</date><risdate>2013</risdate><abstract>Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidinafto[2,l-d:l',2'-f][l,3,2]dioksafosfepin 4-oksidom ili nekim njegovim derivatom, a posebno sa (1 lbR)-4-hidroksidinafto[2,l-d:r,2'- f][l,3,2]dioksafosfepin 4-oksidom, kao agensom za rezoluciju.
The present invention relates to a process for isolating (αS, R)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL |
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