PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL

PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL

Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidina...

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Bibliographische Detailangaben
Hauptverfasser: BADER, Thomas, HORNS, Stefan, PORSTMANN, Frank, Ralf
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Ovaj pronalazak se odnosi na Proces za izolovanje (S, R)-6-bromo-[2-(dimetilamino)etil]-2- metoksi-l-naftalenil-fenil-3-kinolinetanola iz mešavine stereoizomemih formi 6-bromo-[2- (dimetilamino)etil]-2-metoksi-l-naftalenil-fenil-3-kinolinetanola uz pomoć optičke rezolucije sa hiralnim 4-hidroksidinafto[2,l-d:l',2'-f][l,3,2]dioksafosfepin 4-oksidom ili nekim njegovim derivatom, a posebno sa (1 lbR)-4-hidroksidinafto[2,l-d:r,2'- f][l,3,2]dioksafosfepin 4-oksidom, kao agensom za rezoluciju. The present invention relates to a process for isolating (αS, R)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- -phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.