Macrocyclic derivatives for the treatment of proliferative diseases

The invention relates to compounds of formula (I)(I)wherein the substituents are defined in the disclosure and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds (I) and their salts, and to the uses thereof. The compounds and salts (I) inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer. Invenţia se referă la compuşi cu formula (I)(I)unde substituenţii sunt definiţi în descriere şi la sărurile farmaceutice acceptabile ale acestora, la compoziţii farmaceutice ce conţin compuşii (I) şi sărurile lor şi la utilizarea acestora. Compuşii şi sărurile (I) inhibă kinaza limfomului anaplastic (ALK) şi/sau EML4-ALK şi sunt utili pentru tratamentul sau ameliorarea tulburarilor proliferative celulare anormale, cum ar fi cancerul. Изобретение относится к соединениям формулы (I)(I)где заместители определены в описании, и к их фармацевтически приемлемым солям, к фармацевтическим композициям, содержащим соединения (I) и их соли, и к их применению. Соединения и соли (I) ингибируют киназу анапластической лимфомы (ALK) и/или EML4-ALK и полезны для лечения или облегчения аномальных клеточных пролиферативных нарушений, таких как рак.