The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans

The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans

The invention relates to medicine, namely to the use of biologically active coordinative compounds of copper from the class of thiosemicarbazonates of transition metals as inhibitors of Candida albicans fungi.Summary of the invention consists in the use as inhibitors of Candida albicans fungi of coo...

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Hauptverfasser: BUZATU-BALACHIN ECATERINA, TAPCOV VICTOR, JALBA ANGELA, GULEA AURELIAN, RUDIC VALERIU, COTOVAIA ALIONA
Format: Patent
Sprache:eng ; rum ; rum
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
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MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
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SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to medicine, namely to the use of biologically active coordinative compounds of copper from the class of thiosemicarbazonates of transition metals as inhibitors of Candida albicans fungi.Summary of the invention consists in the use as inhibitors of Candida albicans fungi of coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine of general formula:I-IIII: R1 = OCH3, R2 = R3 = H; II: R1 = R3 = H, R2 = OCH3; III: R1 = R2 = H, R3 = OCH3. Inventia se refera la medicina, si anume la utilizarea compusilor coordinativi ai cuprului biologic activi din clasa tiosemicarbazonatilor metalelor de tranzitie în calitate de inhibitori ai fungilor din specia Candida albicans.Esenta inventiei consta în utilizarea în calitate de inhibitori ai fungilor din specia Candida albicans a compusilor coordinativi ai cuprului(II) cu 4-(metoxifenil)tiosemicarbazonele 2-benzoilpiridinei cu formula generala:I-IIII: R1 = OCH3, R2 = R3 = H; II: R1 = R3 = H, R2 = OCH3; III: R1 = R2 = H, R3 = OCH3.