Process for the obtaining of an injection oil silver nanodispersion
The invention relates to medicine, namely to a process for the obtaining of an injection oil silver nanodispersion.The process provides for the mixing in a volume ratio of 5:1 of sunflower oil for injection with an aqueous colloidal silver nanodispersion with the size of particles of 5...10 nm, obta...
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Sprache: | eng ; rum ; rum |
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Zusammenfassung: | The invention relates to medicine, namely to a process for the obtaining of an injection oil silver nanodispersion.The process provides for the mixing in a volume ratio of 5:1 of sunflower oil for injection with an aqueous colloidal silver nanodispersion with the size of particles of 5...10 nm, obtained from silver nitrate by precipitation with sodium citrate and stabilized with polyvinylpyrrolidone, at the same time the mixing is carried out under stirring at a speed of 300 vol./min within 15...20 min, then it is separated the aqueous fraction, and the oil nanodispersion with the concentration of colloidal silver of 2.5...5.0 ppm is vacuum-treated at a pressure of 0.085 atm, a temperature of 75...80°C, during 20...30 min and packed in glass vials.The result consists in the possibility of administration of the oil silver nanodispersion by injection.
Invenţia se referă la medicină, şi anume la un procedeu de obţinere a unei nanodispersii uleioase de argint injectabile.Procedeul include amestecarea în raport volumetric de 5:1 a uleiului de floarea-soarelui pentru uz injectabil cu o nanodispersie apoasă de argint coloidal cu dimensiunea particulelor de 5...10 nm, obţinute din azotat de argint prin precipitare cu citrat de sodiu şi stabilizate cu polivinilpirolidonă, totodată amestecarea se efectuează la agitare cu viteza de 300 rot./min timp de 15...20 min, după care se separă fracţia apoasă, iar nanodispersia uleioasă cu concentraţia de argint coloidal de 2,5...5,0 ppm se vacuumează la o presiune de 0,085 atm, temperatură de 75...80°C, timp de 20...30 min şi se ambalează în fiole de sticlă.Rezultatul constă în posibilitatea administrării pe cale injectabilă a nanodispersiei uleioase de argint. |
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