Process for preparing N-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide by reacting the corresponding amine with a 3-halo-propionyl chloride

Prezenta invenţie furnizează un procedeu îmbunătăţit pentru prepararea derivaţilor de aminopirimidină sau a sărurilor acceptabile farmaceutic ale acestora care au o activitate inhibitorie selectivă asupra kinazelor, în special asupra kinazelor proteice pentru receptorii factorului de creştere epidermal. Şi de asemenea, prezenta invenţie furnizează noi intermediari, utili pentru respectivul procedeu, şi procedee pentru preparea acestora. The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additionally, the present invention provides novel intermediates useful for said process and processes for preparing the same.