PRODUCTION ET UTILISATION DE PORPHYRINES

A method and a pharmaceutical composition for killing mammalian tumour cells is disclosed and entails cells being exposed to light in the presence of a photoactivatable tetrapyrrole, the improvement consisting in the fact that these cells are treated with a compound which inhibits the enzymatic conv...

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Bibliographische Detailangaben
Hauptverfasser:	HAILING BLAIK, WITKOWSKI DEBRA
Format:	Patent
Sprache:	fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method and a pharmaceutical composition for killing mammalian tumour cells is disclosed and entails cells being exposed to light in the presence of a photoactivatable tetrapyrrole, the improvement consisting in the fact that these cells are treated with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in these cells, which brings about an accumulation of protoporphyrin IX in these cells. A process for the preparation of protoporphyrin IX is also disclosed and comprises the cultivation of eukaryotic microalgae in the presence of a protoporphyringen oxidase inhibitor.