CONSTRUCTIONS DE PROTÉINES DE FUSION POUR UNE MALADIE ASSOCIÉE AU COMPLÉMENT

CONSTRUCTIONS DE PROTÉINES DE FUSION POUR UNE MALADIE ASSOCIÉE AU COMPLÉMENT

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Fur...

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Bibliographische Detailangaben
Hauptverfasser: KALLED, Susan L, TAYLOR, Frederick Robbins, VIOLETTE, Shelia Marie, CARAVELLA, Justin Andrew, FAHNOE, Kelly C, STARK, Ellen Garber, HOLERS, Vernon Michael, STOREK, Michael, HUANG, Cheng Ran, CURTIS, Michael Steven
Format: Patent
Sprache:fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.