PROTÉINES DE LIAISON MULTI-SPÉCIFIQUES SE LIANT À BCMA, NKG2D ET CD16, ET MÉTHODES D'UTILISATION

PROTÉINES DE LIAISON MULTI-SPÉCIFIQUES SE LIANT À BCMA, NKG2D ET CD16, ET MÉTHODES D'UTILISATION

Multi-specific binding proteins that bind to and kill human cancer cells are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer. The cancer can be B-cell maturation antigen (BCMA)-expressing cancer. The multi-specific binding proteins provide...

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Bibliographische Detailangaben
Hauptverfasser: CHANG, Gregory P, PRINZ, Bianka, WAGTMANN, Nicolai, CHEUNG, Ann F, GRINBERG, Asya, HANEY, William, BIGELOW, Mitchell, LUNDE, Bradley M
Format: Patent
Sprache:fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Multi-specific binding proteins that bind to and kill human cancer cells are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer. The cancer can be B-cell maturation antigen (BCMA)-expressing cancer. The multi-specific binding proteins provided herein exhibit high potency and maximum lysis of target cells compared to anti-BCMA monoclonal antibodies.