INHIBITEURS DE TGF?1 SÉLECTIFS SELON L'ISOFORME À AFFINITÉ ÉLEVÉE

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

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Bibliographische Detailangaben
Hauptverfasser:	CHAPRON, Christopher, WAWERSIK, Stefan, STEIN, Caitlin, BUCKLER, Alan, COOPER, Anthony, JACKSON, Justin, W, LIN, Susan, SCHURPF, Thomas, DAGBAY, Kevin, B, CAPILI, Allan, DATTA, Abhishek, SALOTTO, Matthew, AVERY, Andrew, MARTIN, Constance, LITTLEFIELD, Christopher, CARVEN, Gregory, J
Format:	Patent
Sprache:	fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.