CONSTRUCTIONS D'ANTICORPS BISPÉCIFIQUES DIRIGÉS CONTRE MUC17 ET CD3

The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the inventio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ROSS, Sandra, PENDZIALEK, Jochen, RAUM, Tobias, CHEN, Irwin, WAHI, Joachim, BLÜMEL, Claudia, DAHLHOFF, Christoph, NAHRWOLD, Elisabeth, BAILIS, Julie, ARVEDSON, Tara
Format:	Patent
Sprache:	fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3E chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.