Composition de vaccin combinée pour administration multiple

La présente invention concerne une composition immunogène à doses multiples pour un vaccin combiné multivalent, dans laquelle (i) le vaccin combiné multivalent contient un vaccin contre la coqueluche vaccin à cellules entières (wp) ou un vaccin contre la coqueluche acellulaire(ap), et un vaccin contre la polio inactivé sabin (sipv) ; et (ii) la composition contient du 2-phénoxyéthanol (2-pe) et du formaldéhyde (hcho) en tant que conservateurs ; et un procédé de préparation d'une composition immunogène à d The present invention relates to a multiple-dose immunogenic composition for a multivalent combination vaccine, in which (i) the multivalent combination vaccine contains a whole cell pertussis (wP) vaccine or acellular pertussis (aP) vaccine, and a Sabin inactivated polio vaccine (sIPV); and (ii) the composition contains 2-phenoxyethanol (2-PE) and formaldehyde (HCHO) as preservatives; and a method for preparing a multiple-dose immunogenic composition for a multivalent combination vaccine. It was confirmed that the combination of 2-phenoxyethanol and formaldehyde according to the present invention is an excellent preservative capable of maintaining antimicrobial ability and that it can be effectively used for providing a multiple-dose composition maintaining antimicrobial ability of combination vaccine, thus the composition of the present invention can be effectively used in the multiple-dose combination vaccine industry.