ANALOGUES NUCLÉOSIDIQUES 5'-SUBSTITUÉS

ANALOGUES NUCLÉOSIDIQUES 5'-SUBSTITUÉS

The present invention relates to novel 5′-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HERGUETA, Antonio Rodriguez, CORTEZ, Guillermo S, GROGAN, Michael John, WOODS, Timothy Andrew, JAMISON, James Andrew, BONDAY, Zahid Quyoom, DAHNKE, Karl Robert, WATSON, Brian Morgan
Format: Patent
Sprache:fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel 5′-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemias including acute myeloid leukemia, and lymphomas.