BENZIMIDAZOLES SUBSTITUES ET PROCEDES DE PREPARATION

L'invention concerne des procédés de préparation de nouveaux composés benzimidazoles substitués de formule (I) utiles pour le traitement de troubles à médiation par kinase, où R1, R2, R3, R4, a, b, et c sont définis au sein de la formule (I). New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.