DERIVES D-HOMO-9, 10-SECOCHOLESTA-23-YNE-3,25-DIOL

DERIVES D-HOMO-9, 10-SECOCHOLESTA-23-YNE-3,25-DIOL

Compounds of formula I: wherein the dotted carbon-carbon bond in the D-ring is C-C or C=C; C(R,R) is CH2 or C=CH2, R1 is H, F or OH, R2 and R3 are each independently C1-4-alkyl or CF3, or together with the carbon to which they are bound form C3-6-cycloalkyl. are useful in the treatment of vitamin D...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WOLFGANG PIRSON, MARC MULLER, PIERRE BARBIER, FRANZ BAUER, PETER MOHR
Format: Patent
Sprache:fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds of formula I: wherein the dotted carbon-carbon bond in the D-ring is C-C or C=C; C(R,R) is CH2 or C=CH2, R1 is H, F or OH, R2 and R3 are each independently C1-4-alkyl or CF3, or together with the carbon to which they are bound form C3-6-cycloalkyl. are useful in the treatment of vitamin D dependent disorders, such as psoriasis, leukemia; acne and seborrhoic dermatitis; osteoporosis hyperparathyroidism accompanying renal failure; and multiple sclerosis.