A TECHNIQUE FOR IDENTIFYING AND SORTING LIVE, UNLABELED CELLS BY TELOMERE LENGTH

The invention pertains to a method for identifying and sorting live, label-free mesenchymal stromal cells (MSCs) by size, which correlates with their telomere length. This can be applied in regenerative medicine and cosmetology. The method for identifying and sorting live, unlabelled cells includes...

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Bibliographische Detailangaben
Hauptverfasser:	DEHTJARS, Jurijs, SOROKINS, Hermanis, BĒRZIŅŠ, Uldis, ŅIKUĻŠINS, Sergejs
Format:	Patent
Sprache:	eng ; lav
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention pertains to a method for identifying and sorting live, label-free mesenchymal stromal cells (MSCs) by size, which correlates with their telomere length. This can be applied in regenerative medicine and cosmetology. The method for identifying and sorting live, unlabelled cells includes sorting MSCs into a certain number of subsets based on their size using dielectrophoresis by polarizing cells in the spatial gradient of the electrical field. Since MSC size correlates with their telomere length, this method allows the indirect separation of live, label-free MSCs from a heterogenous stromal cell population according to their telomere length. The sorted live MSC subset with longer telomeres can be used in cell therapies, in the development of organ-on-a-chip platforms (3D in vitro models) to study aging changes in organs, in the creation of new drugs or in studies of age-related diseases.