5-(4-CHLOROBUTHYL)-PYRANO[2,3-D]PYRIMIDIN-2,4,7(3H)-TRIONE AND 5-ALKYL-2-THIOXO-1H-PYRANO[2,3-D]PYRIMIDIN-4,7-DIONE AS NOVEL SELECTIVE LIGANDS AND SYNTHONS OF HYDROXYCARBOXYLIC ACID HCA2 (GRP109A) CLASSES RECEPTORS

5-(4-CHLOROBUTHYL)-PYRANO[2,3-D]PYRIMIDIN-2,4,7(3H)-TRIONE AND 5-ALKYL-2-THIOXO-1H-PYRANO[2,3-D]PYRIMIDIN-4,7-DIONE AS NOVEL SELECTIVE LIGANDS AND SYNTHONS OF HYDROXYCARBOXYLIC ACID HCA2 (GRP109A) CLASSES RECEPTORS

The invention relates to the field of biochemistry and medicine, particularly to 5-(4-chlorobuthyl)-pyrano[2,3-d]pyrimidin-2,4,7(3H)-trione and 5-alkyl-2-thioxo-1H-pyrano[2,3-d]pyrimidin-4,7-diones as ligands of hydroxycarboxylic acid (HCA) class receptors (including niacin group), useable in medici...

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Bibliographische Detailangaben
Hauptverfasser: BR VERE IMANTA, PETROVSKA RAMONA, MANDRIKA ILONA, DUBURS GUN RS, ULDRI IS J NIS, KLOVI Š J NIS, POIK NS J NIS, V GANTE BRIGITA, BISENIEKS EGILS
Format: Patent
Sprache:eng ; lav
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention relates to the field of biochemistry and medicine, particularly to 5-(4-chlorobuthyl)-pyrano[2,3-d]pyrimidin-2,4,7(3H)-trione and 5-alkyl-2-thioxo-1H-pyrano[2,3-d]pyrimidin-4,7-diones as ligands of hydroxycarboxylic acid (HCA) class receptors (including niacin group), useable in medicine for prevention and treating of diseases of lipids, cholesterol and carbohydrates metabolism as well as atherosclerotic and inflammatory processes. Izgudrojums attiecas uz bioķīmiju un medicīnu, konkrēti uz 5-(4-hlorbutil)-pirano[2,3-d]pirimidīn-2,4,7(3H)-trioniem un 5-alkil-2-tiokso-1H-pirano[2,3-d]pirimidīn-4,7-dioniem kā hidroksi karbonskābju receptoru (HCA) saimes (t.sk., niacīna grupas) ligandiem, kas izmantojami medicīnā lipīdu, holesterīna un cukura vielmaiņas, kā arī aterosklerotisku un iekaisuma procesu normalizēšanai un ārstēšanai.