PROCESS FOR THE INACTIVATION OF GENES WHICH CODE FOR ENZYMES FOR THE CATABOLISM OF PHENYLACETATE, PLASMIDS INVOLVED IN SUCH PROCESS AND STRAINS TRANSFORMED THEREWITH

Process for inactivating genes which code for enzymes of the phenyl acetate catabolism, plasmids containing them and strains transformed therewith. The process applies preferably to the gene pahcA of A.nidulans and to the gene pahA of P. chrysogenum , genes which code respectively for competitor enz...

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Hauptverfasser:	FERNANDEZ CANON,JOSE MANUEL, BARREDO FUENTE,JOSE LUIS, MINGOT ASCENCAO,JOSE MANUEL, RODRIGUEZ SAIZ,MARTA, DIEZ GARCIA,BRUNO, SALTO MALDONADO,FRANCISCO, VITALLER ALBA,ALEJANDRO, PENALVA SOTO,MIGUEL ANGEL
Format:	Patent
Sprache:	eng ; lav
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Process for inactivating genes which code for enzymes of the phenyl acetate catabolism, plasmids containing them and strains transformed therewith. The process applies preferably to the gene pahcA of A.nidulans and to the gene pahA of P. chrysogenum , genes which code respectively for competitor enzymes for this substrate with the biosynthetic enzymes of penicillin. The non expression of said enzymes favors the synthesis of this antibiotic, increasing its production, with a smaller demand of phenyl acetate per culture unit.