METHOD FOR PRODUCING OF COMPLEX ANTIBIOTIC- CYCLOSPORIN AND/OR IT'S COMPONENTS AND METHOD FOR PRODUCING OF TOLYPOCLADIUM VARIUM CULTURE

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrie...

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Hauptverfasser:	MOLNAR NEE ANTAL,ANIKO, TOMORI NEE JOSZT,EVA, AMBRUS,GABOR, HELBER NEE DOBOS,AGOTA, SZELL,VALERIA, JEKKEL NEE BOKANY,ANTONIA, NAGY,KAROLY, MORAVCSIK,IMRE, PALOTAS,BELA, SZABO,ISTVAN MIHALY, ERDEI,JANOS, ANDOR,ATTILA, POLYA,KALMAN, BUZASI,KAROLY, TOTH-SARUDY,EVA, SZASZHEGYESI,VILMA, SANTHA,GY÷RGY, KINCZIL,KALMAN, KISS,LAJOS, ALBRECHT,KAROLY, DELI NEE KONSZKY,ETELKA, MAKADI,BELA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 DEG to 30 DEG C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.