APTAMER QQ-4 TARGETING HUMAN HIGH-INVASIVE CHOROIDAL MELANOMA AND APPLICATION THEREOF

The present application provides an aptamer QQ-4 targeting human high-invasive choroidal melanoma and application thereof. Nature characterization of the aptamer QQ-4 and identification of the target molecules are helpful to discover tumor markers for diagnosis and targeted therapy of choroidal melanoma. The prepared aptamer is capable of specifically recognizing high-invasive choroidal melanoma cells and choroidal melanoma tissues, has high affinity, no immunogenicity and small molecular weight, and can be chemically synthesized in vitro; different parts of the aptamer are easily modified and substituted. Meanwhile, the sequence of the aptamer is stable, thus it can be stored and labeled conveniently. When human choroidal melanoma cells are detected using the aptamer of the disclosure, the operation is simpler and rapider. Furthermore, the synthesis cost of the aptamer of the disclosure is lower than that of antibody preparation, with short cycle and good reproducibility.