PROCESS FOR THE INACTIVATION OF GENES WHICH CODE FOR ENZYMES FOR THE CATABOLISM OF PHENYL ACETATE, PLASMIDS INVOLVED IN SUCH PROCESS AND STRAINS TRANSFORMED THEREWITH

Procedure for the inactivation of genes that code for phenylacetate catabolism enzymes, plasmids containing them, and strains transformed with them. The procedure is preferably applied to the phacA gene of A. nidulans and to the pahA gene of P. chrysogenum, genes which code respectively for enzymes...

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Hauptverfasser:	MINGOT-ASCENCAO,JOSE MANUEL, DIEZ-GARCIA,BRUNO, FERNANDEZ-CANON,JOSE MANUEL, VITALLER-ALBA,ALEJANDRO, SALTO-MALDONADO,FRANCISCO, BARREDO-FUENTE,JOSE LUIS, PENALVA-SOTO,MIGUEL ANGEL, RODRIGUEZ-SAIZ,MARTA
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Procedure for the inactivation of genes that code for phenylacetate catabolism enzymes, plasmids containing them, and strains transformed with them. The procedure is preferably applied to the phacA gene of A. nidulans and to the pahA gene of P. chrysogenum, genes which code respectively for enzymes competing for this substrate with penicillin biosynthesis enzymes. The non-expression of these enzymes has a beneficial effect on the synthesis of this antibiotic, increasing its yield, with a lower phenylacetate demand per unit of culture.