2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

This invention relates to compounds of general Formula (I)and pharmaceutically acceptable salts thereof, in which R1, R1a, R2, R3, R4, and (R5)a are as defined herein, to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts thereof, and to methods of using such...

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Bibliographische Detailangaben
Hauptverfasser: JALAIE, Mehran, ZHOU, Ru, TUTTLE, Jamison Bryce, MCTIGUE, Michele Ann, NAIR, Sajiv Krishnan, ZHOU, Dahui, SCHMITT, Anne-Marie Dechert, AHMAD, Omar Khaled, JOHNSON, Ted William, HE, Mingying, DEL BEL, Matthew L, GALLEGO, Rebecca Anne, KANIA, Robert Steven
Format: Patent
Sprache:eng ; lit
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention relates to compounds of general Formula (I)and pharmaceutically acceptable salts thereof, in which R1, R1a, R2, R3, R4, and (R5)a are as defined herein, to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts thereof, and to methods of using such compounds, pharmaceutically acceptable salts and compositions for the treatment of abnormal cell growth, including cancer.