BCMA (CD269/TNFRSF17) - BINDING PROTEINS

The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PARMAR, Radha Shah, CLEGG, Stephanie Jane, WATTAM, Trevor Anthony Kenneth, LEWIS, Alan Peter, CRAIGEN, Jennifer L, HAMBLIN, Paul Andrew, ALGATE, Paul, MAYES, Patrick
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.