MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflamma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ANDREWS, Steven Wade, CONDROSKI, Kevin Ronald, SEO, Jeongbeob, HAAS, Julia, KOLAKOWSKI, Gabrielle R, JIANG, Yutong, YANG, Hong-Woon, ZHAO, Qian
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula: