IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS

The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogues consisting of a DNA- alkylating and a DNA-binding part, and still f...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	JOOSTEN, Johannes Albertus Frederikus, HUIJBRGTS, Tijl, BEUSKER, Patrick Henry, ELGERSMA, Ronald Christiaan, SPIJKER, Henri Johannes, COUMANS, Rudy Gerardus Elisabeth, MENGE, Wiro, DE GROOT, Franciscus Mariuns Hendrikus
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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