IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS

IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS

The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogues consisting of a DNA- alkylating and a DNA-binding part, and still f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JOOSTEN, Johannes Albertus Frederikus, HUIJBRGTS, Tijl, BEUSKER, Patrick Henry, ELGERSMA, Ronald Christiaan, SPIJKER, Henri Johannes, COUMANS, Rudy Gerardus Elisabeth, MENGE, Wiro, DE GROOT, Franciscus Mariuns Hendrikus
Format: Patent
Sprache:eng ; lit
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogues consisting of a DNA- alkylating and a DNA-binding part, and still further into corresponding antibody-drug conjugates.