PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES

PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES

The invention relates to a process for manufacturing the compound of formula I wherein R is n -propyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is n -propyl, or a sal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHINDELHOLZ, Ivan, FUNEL, Jacques-Alexis, ABELE, Stefan
Format: Patent
Sprache:eng ; lit
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for manufacturing the compound of formula I wherein R is n -propyl, or a salt thereof, said process comprising the reaction of the compound of formula I-1 wherein X is Br, Cl or F, or a salt thereof, with the compound of formula I-2 wherein R is n -propyl, or a salt thereof, in the presence of a base, and, when X is Br or Cl, in the presence of tetra- n -butyl ammonium fluoride hydrate or cesium fluoride.