HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

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Hauptverfasser: ZAPF, Christoph Wolfgang, XING, Li, WENNERSTÅL, Göran Mattias, SCHNUTE, Mark Edward, KAILA, Neelu, MEYERS, Marvin Jay, BLINN, James Robert, MENTE, Scot Richard, THORARENSEN, Atli, ZAMARATSKI, Edouard, FLICK, Andrew Christopher, JONES, Peter, KIEFER, James Richard Jr, KURUMBAIL, Ravi G
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creator ZAPF, Christoph Wolfgang
XING, Li
WENNERSTÅL, Göran Mattias
SCHNUTE, Mark Edward
KAILA, Neelu
MEYERS, Marvin Jay
BLINN, James Robert
MENTE, Scot Richard
THORARENSEN, Atli
ZAMARATSKI, Edouard
FLICK, Andrew Christopher
JONES, Peter
KIEFER, James Richard Jr
KURUMBAIL, Ravi G
description The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
format Patent
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF
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