PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2

Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of "all-trans" configuration to monoprenyl derivative of menadiol following "1+6" synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the prot...

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Bibliographische Detailangaben
Hauptverfasser:	DZIKOWSKA, Jadwiga, WITKOWSKI, Stanislaw, JEDYNAK, Lukasz, GUTOWSKA, Regina, WINIARSKI, Jerzy, KRAJEWSKI, Krzysztof, KUBISZEWSKI, Marek, WALEJKO, Piotr, KUTNER, Andrzej, MORZYCKI, Jacek, NAPIÓRKOWSKI, Marek, BAJ, Aneta
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of "all-trans" configuration to monoprenyl derivative of menadiol following "1+6" synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z′ and Z′ represent H or one of Z′ and Z″ represents H and the other represents phenylsulfonyl group -SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.