GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
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| creator | BESKROVNAYA, Oxana CELATKA, Cassandra XIANG, Yibin SCHEULE, Ronald LEONARD, John BOURQUE, Elyse SKERLJ, Renato MAKINO, Elina METZ, Markus NATOLI, Thomas GOOD, Andrew CABRERA-SALAZAR, Mario HIRTH, Bradford HUSSON, Herve MARSHALL, John ZHAO, Zhong CHENG, Seng JANCSICS, Katherine |
| description | The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer. |
| format | Patent |
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| language | eng ; lit |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS |
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