GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

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Bibliographische Detailangaben
Hauptverfasser:	BESKROVNAYA, Oxana, CELATKA, Cassandra, XIANG, Yibin, SCHEULE, Ronald, LEONARD, John, BOURQUE, Elyse, SKERLJ, Renato, MAKINO, Elina, METZ, Markus, NATOLI, Thomas, GOOD, Andrew, CABRERA-SALAZAR, Mario, HIRTH, Bradford, HUSSON, Herve, MARSHALL, John, ZHAO, Zhong, CHENG, Seng, JANCSICS, Katherine
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to inhibitors of glucosylceramide synthase (GCS) of formula (I) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.