JCV NEUTRALIZING ANTIBODIES

JCV NEUTRALIZING ANTIBODIES

In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody su...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CAMERON, Thomas, RUSHE, Mia, WANG, Deping, DAY, Eric, ARNDT, Joseph, SIMON, Kenneth, CARAVELLA, Justin
Format: Patent
Sprache:eng ; lit
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.